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Other info: I'm using Ubuntu 21.04, Mesa 21.0.1, Wine 6.0.1-stable, with an Intel HD Graphics 4000 GPU. However, I don't think quartz is the culprit here, since if I use LIBGL_ALWAYS_SOFTWARE=1 the game loads as expected, but I only get around ~2 fps, as opposed to 60. Furthermore, I've tried multiple versions of Valve's Proton and reinstalling the game, but both didn't work. I'm using a clean 32-bit wineprefix where I haven't used Winetricks nor messed with winecfg libraries. I suspect the issue lies in WineD3D, since I have the "4GB-aware" exe patch (that is Linux compatible, according to users on Reddit and the patch's readme.) (and I tried running the game both with and without the patch), and memory doesn't seem like it is struggling from what I've tested. My clean version of Fallout: New Vegas (from GOG) crashes as soon as I leave Doc Mitchell's house.
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